Story-related and cannot be missed, this trophy will pop after you enter the back-up escape tunnel.

Check out my walkthrough for specifics on how to get this trophy:
http://www.ps3trophies.org/forum/sam...tml#post942242

Story-related and cannot be missed, this trophy will pop after using Charlie Ho-Tep at the warehouse after you have directed the clones to go to the toybox.

Check out my walkthrough for specifics on how to get this trophy:
http://www.ps3trophies.org/forum/sam...tml#post942242

Story-related and cannot be missed. This trophy will pop after you defeat this episode's "boss."

Check out my walkthrough for specifics on how to get this trophy:
http://www.ps3trophies.org/forum/sam...tml#post942242

Story-related and cannot be missed, you will get this trophy after you have fully interrogated Momma Bosco, Papierwaite and Stinky.

Check out my walkthrough for specifics on how to get this trophy:
http://www.ps3trophies.org/forum/sam...tml#post942242

In Momma Bosco's lab you will need to use the dimensional destabilizer in order to acquire the Cthonic Destroyer. Each of the knobs controls a different aspect of what happens to Sam. You need to have the 4 following things happen to him:

Mood - Sam needs to be giggling .
Fate - Use the future vision power, the correct one will show a giant Max dropping Sam into his mouth.
Effect - A flash of light, you will know this when you see it and Max will make a comment to the effect of it being bright.
Encounter - Sam needs to encounter the insects, use the mind reading card to find out what Sam encountered.

While it seems that the combination from left to right changes each game it always contains a 1 2 3 3. You can always save beforehand and after you find the right combo just reload and put it in.

In the Warehouse/Docks area where Sal is, use the mind reading cards on the newspaper stand.

Here is a complete list of things to use the Ventriloquism power on. Thanks to mjc0961 for compiling the list.

Docks/Warehouse Area
Sal
Bluster Blaster
warehouse door

Stinky's Diner
dogglegangers
juke box
Stinky
Flint
Grandpa Stinky

Bosco Tech
Superball (just standing there)
Harry (just standing there)
Superball (during seance)
Harry (during seance)
picture of Uncle Morty
closet (take the elevator to the upper floor)
Momma Bosco's ghost

Cloning Pod area
important cloning pod
Sal
Stinky
Momma Bosco

Museum Office
window
Papierwaite
Norrington/Yog Soggoth

Statue of Liberty
Charlie Ho-tep
Statue of Liberty
Sam

The things you need to change to turn into are:
Desoto - available in stinky's Diner
Cake - In the warehouse area (cannot be missed)

The four following items are available by changing the music sheet at the final area and reading Sam's mind:
Charlie Ho-tep (Not Missable)
Eternal Darkness
Tongue of Flame
Mind Plague

Use the mind reading cards on the following people.

Docks/Warehouse Area
Sal
Clones
Bluster Blaster

Stinky's Diner
Stinky
Flint
Grandpa Stinky

Bosco Tech
Superball (just standing there)
Harry (just standing there)
Superball (during seance)
Harry (during seance)
Momma Bosco's ghost

Cloning Pod area
Sal
Stinky
Momma Bosco

Museum Office
Papierwaite
Norrington/Yog Soggoth

Statue of Liberty
Charlie Ho-tep
Sam (if you missed him before)

In the clone pod room use Sam's gun on the cavern of clone pods until the trophy pops; this is also needed for the Telltale Loves You trophy.

This trophy requires you to hear a variety of references to past Telltale/Lucasarts games and a few movie references. The complete list and their source is as follows. Thanks to Nicholi_Anhelo for compiling the list.

Max
*When you talk to Max, pick the Random option multiple times and he'll mention several different characters from previous seasons like The Devil, Santa Claus, and The C.O.P.S.

Stinky's Diner
*Talk to Skun-ka'pe at the beginning of the game multiple times. Eventually, Sam will offer him a bottle of Banang (Season 2 and Tales of Monkey Island). [Thanks to dab198]
**IMPORTANT** Must be done BEFORE using the radio in the diner.

*Have Max use psychic ventriloquism on the Jukebox. He'll start to sing "I remember my childhood in Brighton..." before quickly being stopped by Sam. (Sam & Max: Hit the Road) [Thanks to mjc0961]
**IMPORTANT** Must be done BEFORE helping Stinky get out of the diner.

Bosco Tech
*One of the dialogue options with Momma Bosco (the first one asking about the Clone Master) will elicit a reaction from Max about the Soda Poppers (Season 1).

*Examine the door on the second floor of the room twice. The second time Sam will mention "not being able to hit the road" while the clones are running around. (Sam & Max: Hit the Road) [Thanks to mjc0961]

Cloning Pod area
*Examine the Dispenser (from Team Fortress 2) in the corner of the room. If you do it enough times, Sam will hit the dispenser with a wrench until it dispenses some Banang. When you try to get it, the dispenser will retract. Afterwords the item is unusable.

*Examine the Tentacles after you've spoken with Norrington and heard about the Cthonic destroyer. When you examine them, Max will mention wishing it was a friendly green tentacle (Day of the Tentacle).

*Use Sam's Gun on the clone pods. The things that the main computer says after a pod is shot reference a number of things (THX, 2001 A Space Odyssey, Les Miserables, The Hitchhiker's Guide to the Galaxy, "In the Year 2525" by Zager & Evans, "58008" spelling Boobs when flipped upside down on a calculator, and Fahrenheit 451).

*When you use the Cthonic Destroyer on the Tentacles, Max will shout out "UNHOLY THIS!" (Tales of Monkey Island) [Thanks to Bucket]

Museum Office
*Examine the phone in Paperwaite's office twice and Sam will mention wanting to talk to his shrink, who is still on vacation. (Sybil from Seasons 1 and 2).