Overview
Estimated Trophy Difficulty: 2.5/10
Offline Trophies: 7, 12, 6, 1
Online Trophies: 0
Estimated Time to Platinum: 6+ Hours
Minimum Playthroughs Required: 1
Missable Trophies: None (Case Selection)
Glitched Trophies: 1 (CSI: Fatal Conspiracy)
Step One: Case Completion
Case One
Upon starting the case you will unlock Thanks for Playing. Click on your PDA and select options and then Case File > Reconstructions > Video for three further freebie trophies, Under the Hood, Reading is Fun and I Like to Watch. This case is the easiest to unlock the Cunning, Skill and Thoroughness trophies. If you follow the Case Walkthrough and/or the video listed under their trophy descriptions, you will be guaranteed Fool Me Once, Can't Get Fooled Again, Human Polygraph, Test Tube Washer, Research Grant, Technically Perfect, Thorough Enough, Darn It, Close Counts After All and No Stone Overturned along with Not Up To Code and Flash Baked.
Case 2
There are two trophies specific to the second case. The first trophy requires you to collect all evidence. For a full list of evidence and it's location, refer to Scavenger Hunt. The final trophy, Planting Evidence, is acquired after completing the case.
Case 3
There are three trophies specific to the third case. After receiving the security records confirming Jayne Barrett's alibi, run a document analysis to find something interesting. This will unlock Sunday, Sunday, Sunday!. Later in the case you will unlock John Barrett's bedroom. Pick up the used lingerie on the bed and analyse it to find two samples. Return to the lab and check the DNA samples to unlock A Tough Job. The final trophy, Tapped Out, will unlock after completing the case.
Case 4
There are two trophies specific to the fourth case. When talking to Veronica for the second time in the interrogation room she'll claim that they were only friends, Use Manny's Cellphone to refute this claim. Next she'll claim that Jessie always go to the carwash alone, use the earring to refute this claim. Next talk to Will. When he denies a relationship, use the cellphone to unlock He Said, She Said. The final trophy, All Washed Up, will unlock after completing the case.
Case 5
There are two trophies specific to case five. Inside one of the boxes in the Gleason Family Self-Storage, there will be some blank papers. Head back to the lab and perform a document analysis to reveal it's contents. Near the end of the case you will unlock Beatriz Salazar's hideout. Check near the barrels to find a Hard Drive. Take it back to the lab and run a Computer Analysis to unlock Smoke The Hive. The final trophy, Boss Fight will unlock after completing the case. If this is your last case, you will also unlock CSI: Fatal Conspiracy
Step Two: Clean Up
At this point, the only trophies you may be missing are those that relate to Cunning, Thoroughness and Skill. The easiest way to obtain these trophies is to play through Case One again as it is quick and does not contain any advanced analysing. Make sure to check your stats via the case files on your PDA regularly. If Cunning or Skill is ever below 100%, you must restart the case. If you're worried about failing an analysis, make a save first and reload it if you mess up. Refer to each of the 100% trophies for details about failing and locations.
[PS3T Would Like to Thank ShadowStrife for this Road Map]